Common food additive may harm gut health: Study

A common additive used in many food items such as chewing gum and mayonnaise may have a substantial and harmful influence on human gut health, a study has found. Published in the journal Frontiers in Nutrition, the study investigated the health impacts of food additive E171 (titanium dioxide nanoparticles) which is used in high quantities in foods and some medicines as a whitening agent.

Found in more than 900 food products such as chewing gum and mayonnaise, E171 is consumed in high proportion everyday by the general population, said researchers from the University of Sydney in Australia.

The study in mice found that consumption of food containing E171 has an impact on the gut microbiota -- the trillions of bacteria that inhabit the gut -- which could trigger diseases such as inflammatory bowel diseases and colorectal cancer.

"The aim of this research is to stimulate discussions on new standards and regulations to ensure safe use of nanoparticles in Australia and globally," said Associate Professor Wojciech Chrzanowski, from the University of Sydney.

While nanoparticles have been commonly used in medicines, foods, clothing, and other applications, the possible impacts of nanoparticles, especially their long term effects, are still poorly understood.

Titanium dioxide consumption has considerably increased in the last decade and has already been linked to several medical conditions, and although it is approved in food, there is insufficient evidence about its safety.

Increasing rates of dementia, auto-immune diseases, cancer metastasis, eczema, asthma, and autism are among a growing list of diseases that have been linked to soaring exposure to nanoparticles. "It is well established that dietary composition has an impact on physiology and health, yet the role of food additives is poorly understood," said Chrzanowski.

"There is increasing evidence that continuous exposure to nanoparticles has an impact on gut microbiota composition, and since gut microbiota is a gate keeper of our health, any changes to its function have an influence on overall health," Chrzanowski said.

"This study presents pivotal evidence that consumption of food containing food additive E171 (titanium dioxide) affects gut microbiota as well as inflammation in the gut, which could lead to diseases such as inflammatory bowel diseases and colorectal cancer," he said.

"Our research showed that titanium dioxide interacts with bacteria in the gut and impairs some of their functions which may result in the development of diseases," said Associate Professor Laurence Macia from the University of Sydney.

"We are saying that its consumption should be better regulated by food authorities," Macia said.

"This study investigated effects of titanium dioxide on gut health in mice and found that titanium dioxide did not change the composition of gut microbiota, but instead it affected bacteria activity and promoted their growth in a form of undesired biofilm.

"Biofilms are bacteria that stick together and the formation of biofilm has been reported in diseases such as colorectal cancer," said  Macia.